YOUR MISSION: Explain “Time.” YOUR REWARD: $5 Amazon gift card. GO!

Last week, my choir went on tour in New Orleans. I had a blast, and while I was spending 8 hours on a bus between NOLA and Memphis, I overheard somebody talking about time at the same time that the bus passed a billboard with a random picture of an alien…

You guys know me. My mind wandered, and I came up with the idea for the first ever MPSN contest!!! Since this is the first one, and I need to know how well this will catch on, I’m setting the prize as a $5 online gift card to Amazon.com. It’s not a huge amount, but you can find $5 stuff there AND if you think of it as a discount, it’s one hell of a discount… especially for 5 minutes of effort!!

Without further adieu, here are the rules:

  1. Leave a comment on this post explaining the idea of “time” to Rob the Alien (in fewer than 200 words). On his planet, there’s no such thing as “time.” You can be as creative as you wish… in fact, we recommend it. We won’t actually count all the words and disqualify you after 200, but if it’s too long we may not read it.
  2. NO profanity. If you cuss, you’ll be automatically dropped from competition. No exceptions.
  3. Use a legit email address. You can use a fake one if you’d like, but we can’t send you the code for the gift card if the email you use is fake.

That’s it for rules — pretty straightforward. The winner will be chosen one week from tonight (Valentine’s Day). Perfect timing to catch some holiday deals!

And remember, this is all just for fun. It’s an easy way to make a few bucks. Give it a go.

Good luck to you!

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A Good Pun that Deserves Recognition for Creativity

“So I went to the doctor the other day because I wasn’t feeling well. He asked me to describe anything I had eaten in the last few days that might upset my stomach. I told him that ever since I ate the jello with red number 40 food coloring, I had felt like i had DYED a little inside.”

- Props to my good friend Travis Hamm

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What in the FruitFly is a “Hox Gene?”

Have you ever had an interior designer???

Maybe you don’t know it, but you’ve had more than one: Hox Genes. Just like the guys with great hair and perfect taste in wine, hox genes are responsible for the way you get mapped out while mom is pregnant with you.

Let’s start at the beginning… the PG13 version. So mom and dad flirt… FASTFORWARD… you’re now a zygote. Welcome to the world. You’ve got nine months of preparation before you can come out to play, so there’s not a moment to waste. You’ve got a few million cells to produce… time for crazy amounts of mitosis!!

But wait… mitosis produces identical cells. Right? And if all the cells are the same, then you end up with a blob and not a baby… right?

Yup! So there has to be something done to make the cells different. Que the hox genes. Almost immediately after the signals are sent through the cell that say “HEY! We’ve been fertilized!”, the designers are expressed that say “LISTEN LISTEN LISTEN!! I want this arm put over here, and I want you to put that leg over – HEY! You can’t put an ear there! Have you ever HEARD of good taste?!?!?”

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Okokok, so proteins don’t actually talk. But essentially, that’s what hox genes do. They set up the “chemical environment” of the cells, and the other genes that make a baby obey the gradients of…. you know what? I’m getting tongue tied here, so I know you probably don’t know what’s going on.

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Genes are dumb little ugly gremlins that do only what they’re told and nothing more. They all already know their instructions: When your room is painted blue and someone upgrades your cable to digital, make this protein… Don’t ask questions, just do it.
Obviously, all the genes can’t be given those same conditions, or else we’d have the same problem: all the genes would be making all proteins at the same time… BLOB BABY. So, many genes have different conditions, but not all (sometimes it’s better to have more than one gene respond to the same conditions… i’ll write a post on that later).

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NOW, coming full circle! Hox genes are some of the first genes that are expressed during development. The main purpose of the proteins that they make are to SERVE AS THE CONDITIONS THAT TELL OTHER GENES WHEN TO BE EXPRESSED. So let’s say that there’s a cell in the tail region of a fetus puppy that’s expressing hox gene named Mustard. It’s going to release those proteins into the space between cells and those proteins are gonna float around. The farther that any cell is away from that tail cell, the fewer of those hox proteins will be floating around. Eventually, you’ll get to the point that some cells won’t even realize that those proteins are even there… SO THE GENES THAT ARE TURNED ON BY Mustard WON’T BE TURNED ON PAST THAT POINT.

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This means that some cells are going to be expressing different proteins than other cells and NO MORE BLOB BABY!! WOOT!!!

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The Armed Forces of The United Systems of YOU (your immune system)

I’m sure you’ve heard that there’s an army inside you that keeps you healthy despite constant attack from the many millions of outside forces that want nothing more than to use your cellular machinery for their own SICK purposes…

But what I’m guessing that you didn’t know was that your army is no ordinary army. You think you’re fighting off that infection with ointment. PUH-LEEZ!! Before you even begin to unscrew the cap of that tube of NeoSporin, there are already tanks rolling through capillary walls, personalized grenades flying and blowing holes in enemy cells, and the synchronization of the greatest league of suicide bombers that you’ve never heard of!! NeoSporin… HAH!

Neutrophil

There’s really no better place to begin this tour of Base Camp You than with the bravest soldiers that your body has to offer… and boy does it have a lot to offer. Of the ten-or-so thousand immune system soldiers that are surging through your blood vessels at any given time, somewhere between six and seven THOUSAND OF THEM are neutrophils, the best kind of suicide bomber you can get.

Your immune system is only as good as it it because of the thousands of cells that lay their life on the line for the good of the body on a daily basis. When a neutrophil gets word of an invader, it spends no time lolligagging around. These highly focused professionals run right up to the source of the emergency signal and push the red button. BOOM! They let out a mix of toxins that eat up the invader and the soldiers too… and it’s never just one. They pride themselves on this kind of display of patriotism, so there are hundreds that just dive in together. It can get pretty messy, but we’ll get to the clean up crew later…now, moving on…

Eosinophils

This next group of soldiers may not be as numerous as the first, but they’re just as willing to do their job and DO.IT.WELL. The eosinophils are the best trained kamikaze pilots you’ll find on this side of the epidermis. These soldiers are trained to recognize an IgE antibody signal from a mile away, and when they enter fight mode, THEY DO NOT QUIT. They will hunt down that antibody and fly directly into the source thereby releasing their acid bombs, eradicating the enemy… and themselves in the process… but, moving on…

Macrophages and Dendritic Cells

You may be asking yourself where we get out intelligence down here. Well, sonny, we may not have any newfangled sophisticated computing devices, but we have our methods. The macrophages and dendritic cells are the best spies that an old fart like me could ever ask for. *snif. My apologies, this system is just so dagnabbit beautiful, I get emotional sometimes.

But back to brass tax, these spies are ALWAYS undercover. From the moment they leave the hematopoetic tissue they pose as GARBAGEMEN… smooth talkin, quietly in a corner, just mindin’ my own business GARBAGEMEN. And nobody ever notices. You see, they don’t go around raising fuss about intruders. They just clean up what they see… and later, when it’s just them and their supervisor, they unload the goods. Everything they find is cataloged and reported. Sneaky? Yeahhh, we don’t like to brag.

B Lymphocytes

Now, before we go any further up the corporate ladder here, I think it’s high time that I introduce you to the robotics department. Our robotics department is a little different than what you’d think, but similar in many aspects too. You see, the B Lymphocytes are trained to only make one type of device: radio transmitters. It’s truly pathetic when you get down to it. These creatures are so annoying that they are all confined to little rooms scattered across the body.

Remember that mysterious superior of the garbagemen? Well, it turns out that the robotics guys answer to him too. They spend their entire juvenile life perfecting their prototype. Then, when they become adults, they sit in that room and wait for the superior to give them permission to move on to mass production of their transmitter.

I can admit that without those transmitters (I believe you refer to them as “antibodies”), the system would go awry pretty fast… but spending your WHOLE LIFE? Seems a bit overkill to me… but moving on forward…

Whoops, my break is up! I had better get back to work. I’ll pick up where I left off on my next break, but in the meantime, click here to learn more about your immune system and how to take care of it.

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Chemo- Photo- Auto- Hetero- TROPHS!

I remember this in microbiology. It sucked, but maybe my pain can be to your benefit.

This type of “trophy” has to do with the way an organism gets carbon and energy. My teacher didn’t do a good job of explaining this, so it took me FOREVER to get the hang of it, but maybe this will help you decipher the code.

Where does the energy come from?

If it comes from light, then it’s a photo-something-troph. Otherwise, it’s a chemo-something-troph. It’s that simple because, as far as scientists know, organisms on earth only get energy from light or by converting the energy that’s stored in CHEMical compounds (thus the chemo- prefix).

In most cases, an organism is either one or the other photo- or chemo-. In rare cases, however, you’ll encounter an organism that’s both. We call these “mixotrophs.”

Where does the carbon come from?

In order to grow, earthlings need organic “building blocks” in order to make things like skin or muscle or ANY other part of the body (this goes for organisms that don’t have skin or muscle as well). There are two ways to get these carbon compounds: make it yourself or eat something that makes it.

If you’re an organism that makes the carbon compounds yourself, then you’re a something-AUTO-troph. If you eat something-auto-trophs, then you’re a something-HETERO-troph.

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SO…

From what you’ve read, what does it mean to be a CHEMOAUTOTROPH? (don’t read any more until you think you know)

If you said that it means the organism in question consumes its organic carbon compounds instead of making those compounds itself AND it gets its energy from converting chemical energy rather than light… THEN YOU’RE CORRECT!!!

Here’s an easy way to remember:

  • If it uses light for energy, then the term “photo” should be in the name. If not, then it shouldn’t.
  • If it makes its own organic carbon compounds, then the term “auto” should be in the name. Otherwise, no.

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I hope this helps!

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Best of Luck,

Grey

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5 Recordbreaking Cancer Developments That You Haven’t Heard of Yet

1. An injection with ACTIVE viruses

Researchers at Dana-Farber Cancer Institute have discovered a means of tattle-telling on prostate cancers using harmless poxviruses. The injection contains a combination of two viruses that create copies of proteins needed to send signals to the immune system of the patient. One of these proteins is a type that’s exposed on the outside of prostate cancer cells, and the other proteins are a specially designed mix of proteins that screams at the immune system. The principle seems simple, but in clinical trials, it almost doubled the mean life expectancy for patients.

2. A bunch of little metal sticks

This crazy idea comes out of a harmonic research relationship between U California and MIT. This cool treatment consists of the injection of two different types of nanoparticle rods. The first type is made of GOLD; it’s job is to float around in the blood steam and find tumors. Once it’s found them, it enters the tumor and is detected by special machinery. Doctors can use these gold nanosticks to not only locate tumors more efficiently, but they can also heat up the tumors, making them more susceptible to different treatments. (Apparently, these gold nanotubes absorb heat when they are exposed to light from an infrared laser.) The weakened tumor is then open to attack by the second type of nanoparticle rod that’s made of, get this, RUST. Good ole Iron Oxide. It all seems pretty far-fetched to me, but you can’t really argue with numbers… and the success rate in trials thus far has been undefeated.

3. NUKE EM!

Researchers at the University of Oklahoma have had phenomenal results after exposing breast cancers to microwave radiation within 2 hours of chemotherapy. In fact, in their clinical trials, it was discovered that this new technique lowered the need of a mastectomy (surgical removal of the entire breast) from 3 of every 4 women with breast cancer… get ready now… to 7 in EVERY 100 WOMEN!!  That’s not too shabby, if I do say so myself.

4. Practice Multiplication

Ok, so I’ve never heard of Fred Hutchison Cancer Research Institute either, but they’ve made huge discoveries in leukemia treatment since New Years. As I’m sure you know, leukemia destroys the cells of a patient’s immune system, leaving them with nothing to fight off diseases. However, these researchers have developed a means by which to use the stem cells from the leftover blood in umbilical cords to restore life to leukemia patients. In fact, this new technique, which results in 164 times the amount of immune system cells as the best modern treatments, has been shown in clinical trials to not only be more effective and in half the time (from four weeks to two), but of the patients in the trial, 70% show absolutely no sign of the cancer and are leading completely normal lives. Pretty good work.

5. Teach the cells to FIX THEMSELVES

This one is by far the coolest. Scientists at Fox Chase Cancer Center have stumbled upon the chaperonin trainer. Chaperone proteins play a role in making sure new proteins fold to their correct shape, because shape begets function and the wrong shape could lead to certain types of cancers. They have applied this concept to their research and come up with Bortezemib, a protease inhibitor. You see, proteases destroy bad proteins. By inhibiting the cells ability to destroy bad proteins they have forced the cell to re-shape them… with staggering results. In each case of their preliminary research on human cell cultures, they were able to reverse the effects of disease brought on by misshapen proteins because the cells FIXED THE PROTEINS. Although this one hasn’t gone into clinical trials, it shows real promise!

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Read On!

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Grey

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The Three Patterns of Natural Selection

Hey Nerds,

In biology lecture this week, my class is covering the mechanisms of evolution. I needed some extra practice, so what better practice than to explain the concepts to someone else. LUCKY YOU! :) Here goes…

It should be pretty obvious that there’s a serious amount of diversity on Earth – even among individuals of the same species… in the same population! But, life happens. And when the situation changes, sometimes individuals in a population can’t deal with those changes. You already know that when this happens, we call it natural selection. Those individuals that can still deal with the environment after the situation has changed are the ones that we say have been “selected for.”

With that being said, there are three ways that this can occur:

Stabilizing Selection

Remember what we said about there being a lot of diversity? Think about it like this: there are three strains to a species of butterfly (white, gray, and black). The white and black butterflies are what we would refer to as the extremes, and the gray is what we would call an intermediate. Makes sense, yes? Most populations have divisions like this (with extremes and intermediates).

In the case of stabilizing selection, the strains selected for are usually the intermediates. It STABILIZES the species. In terms of our example, this would mean that something is keeping white and black butterflies from being able to survive and reproduce very well. The species is stabilized as mainly gray.

NOTE: this doesn’t mean that there’s any loss of ability to produce offspring that land in the extreme category. Those butterflies can still be produced. However, they don’t have many children.

Directional Selection

Can you guess how this mechanism of selection works? Here’s a hint: it leans toward one direction. ;) To be specific, this means that selection favors ONE extreme over both the other extreme AND the intermediates.

So, if there was some sort of factor that kept black AND gray butterflies from being able to survive and reproduce as well as the white butterflies, then it could be said that selection favors the white butterfly. Because the white butterfly is an extreme, this would be a form of directional selection. It would also be directional selection if the favored butterfly was black.

Disruptive Selection

So now that you have a pretty good idea of how this kinda works you probably know the only other way that this can work.

In the case of disruptive selection, both of the extremes are selected over the intermediates. NO GRAY BUTTERFLIES. It’s kinda like double-directional selection. I can’t think of anything creative at the moment, but you’re a smart person. You can think of something. ;)

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I hope this helps.

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Best of Luck,

Grey

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Things to Know About Genetic Variation

“Blah Blah Blah Natural Selection. Blah Blah Blah Evolution. Blah Blah Blah Mutation. Blah.”

That’s actually written in my notes. Looking through some of my old notes to write this article, I found that quote and it was too good to pass up. Thankfully, I’ve grown a bit since then, and I can better explain this stuff to you (but of course, with the same teenaged angst).

As far as vocab terms go, “genetic variation” is one of the most straightforward ones that you’ll run across. For those of you who are a little slower than others, it means “VARIATION in a population based on GENETIC differences.” Are we all together here again?

Here’s something to keep in mind: you can’t tell differences in genetic variation by simply looking at an individual. Sure, you can look at hair color or eye color, and you’ll probably already know that these differences are based on genetics. BUT not every trait is genetic. Extreme “buff-ness,” for example is a trait that almost all members of the bodybuilder population have. Unfortunately, that’s not based on genetics. THEREFORE, we have to make a difference between GENOTYPE and PHENOTYPE. If you don’t see how that ties in right at this moment, that’s ok… it’s just something to keep in mind.

Discrete Characters vs. Quantitative Characters

Let’s talk turkey. Let’s say, for instance, that there exist only three genes in turkeys: one for feather color, one for gender, and one for everything else. For now, we’re gonna ignore the “everything else” gene and hone in on the other two.

The result of the gender gene is what we’d call a DISCRETE CHARACTER. It’s only got a certain number of results: male or female. There’s not really much of any middle ground there, so it’s a discrete characteristic.

The result of the feather color gene would be understood as a QUANTITATIVE CHARACTER. Although it’s possible that in some species color is either black or white (in which case, it would be discrete), but in most species, colors are the result of a few pigments blending together to give a certain final result. Like the range of browns (from almost white to almost black) in human skin, quantitative characteristics are usually part of a gradient.

If you’re ever having trouble assessing whether a characteristic is discrete or quantitative, ask yourself “are there only a few possibilities for this trait or are there only a few?”

Here’s an example: Is foot size a discrete or quantitative characteristic? (technically this is a trick question, but just follow me here) Because human adults show foot sizes that range from super small to super large, it’s pretty obvious that there are more possibilities than black vs. white. So foot size would be a quantitative character.

Average Heterozygosity

This is going to be the shortest paragraph I’ve written thus far. Average heterozygosity is the percentage of genes in a genome that are heterozygous. Boom. That’s all. If a population of Granny Smith apples had 500 genes, with heterozygosity in around 150 genes, then it could be said that that population has an average heterozygosity of 30%.

It’s actually that simple. But here’s the catch: it can’t measure variation any smaller than whole genes. If there was a mutation in a gene that changed the sequence but NOT the final result, using average heterozygosity would completely overlook that.

Nucleotide Variability

That’s why they invented nucleotide variability. Here’s how it works. Pick one individual from a population; compare his/her genome sequence to that of another individual from the same population. Do this again… A WHOLE LOT. Record results. What this does is tell scientists how much variation there is in the genomes of the population.

For instance, in a population of iPhones, it was found that there are approximately 122 million base pairs in the genome. After comparing the sequences of numerous iPhones, it was observed that any two iPhones differ on average by about 61 million pairs. Therefore, the average nucleotide variability among iPhones in that population was around 50%.

Other Sources of Variation

Those are the big boys that you should really be familiar with, however there are a few others that you should at least recognize.

Geographic Variation – brought about by changes in location that force populations to change in isolation from one another.

Cline – form of geographic variation. However, this is characterized by a gradient between numerous locations. If the percentage of people with a gene for black hair were to increase gradually as you move from Los Angeles to New York, that would be referred to as a cline.

Mutation – The ultimate source of all new alleles. The introduction of new characteristics due to random chance.

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I really hope this helps someone. Be sure to comment.

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Best of Luck,

Grey

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Earth and Ogres’: What do they have in common? Layers!

Earlier I did an article informing you about the Earth’s atmosphere. Well, now I feel that an article should be written about a topic that is equally as important: the layers of the Earth.

When you think about Earth, at least the non-atmospheric portion of it, you get the image of a big round ball of rocks and water. That, to a certain extent is true. But what is on the inside of our planet aside from a wonderful personality. Is Earth just a shallow ball on the inside that is waiting to collapse in on itself or it’s it composed of different layers that in turn are composed of different element and compounds? If you were to guess the latter of the two ideas then you would be correct. Either way, I still think you should read this article.

So, I will start off by listing the different layers of the Earth and then will go more in depth as we proceed through the article. The Earth is composed of four basic layers: crust, mantle, outer core, and inner core. Each of these layers are vastly different from each other and are always changing, sometimes very violently, as time continues. The first and outermost layer is called the crust. This is the ground you walk on or the ocean floors. The second layer is the mantle. This layer is the thickest of all the layers (when the outer and inner core are not combined). The core is what follows the mantle. The core can be broken into two layers: the outer core and the inner core.

Starting from outside and going inward: crust, upper mantle, lower mantle, outer core, and inner core.

Starting from outside and going inward: crust, upper mantle, lower mantle, outer core, and inner core.

As mentioned earlier, the crust is the outermost layer. It is made up of two types of plates: continental and oceanic. As you scan the crust, one would find that it varies in its thickness, ranging from roughly 5 km to 70 km thick. The locations where the crust is thicker is the continental plates whereas the thinner portions are the oceanic plates. Earth’s crust is mainly a composition of alumino-silicates, which are minerals made of aluminum, silicon, and oxygen.

The second layer is called the mantle. The mantle is roughly 2900 km thick and can be divided into the upper mantle and the lower mantle. A majority of our planet’s internal heat can be found in the mantle.     Because of this heat, convection occurs which allows for plate tectonics to take place (I will discuss that in another essay). In the upper mantle there exists what is called the asthenosphere. This part of the mantle is soft and plastic. Pressure is the cause for its characteristics. On top of the asthenosphere is the lithosphere. This layer can both include the uppermost regions of the mantle as well as the crust. The lithosphere is what is broken up into the tectonic plates. I will talk about the stress that is placed on it later when I do seismology. The mantle is composed of Fe,  Mg, Al, Si, and oxygen silicate compounds. In the mantle, the temperatures are extremely hot, ranging from roughly 500 to 900 degrees Celsius and increasing to well over 4,000 degrees Celsius as you approach the core.

The third layer is called the outer core. The outer core is roughly 2300 km thick and made up of a nickel-iron alloy which is in its liquid form. The temperatures in this part of Earth’s interior can soar to around 6100 degrees Celsius. As I mentioned earlier, the outer core is composed of nickel-iron alloy which is able to influence the Earth’s magnetic field due to eddy currents, or Foucault currents, which help to protect us from the solar winds that the Sun emits. Additionally, the reason this alloy is not solid is because the pressure is not strong enough to make it so.

The last layer is the inner core. This solid layer of the planet is the innermost and hottest part of Earth, with temperatures possibly reaching the temperatures as the surface of the sun. It is thought to be composed mainly of iron, this being based off of the abundance of chemical elements in the solar system.

This concludes my article about the layers of the Earth. I will go into the mechanics of seismology in a later article. Thanks for reading!

Photos came from Wikimedia Commons.

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Black Saturday Australian Brushfires

Ok, so I was going to write an article over cloud formation and dynamics but Grey pointed out the Black Saturday brushfires in Australia and I figured that it was an interesting topic to write about and you will see why in this post. I will get back to my normal posts after I write this. Also, I will be posting articles that will go more in depth over some of the environmental/meteorological/climatological/etc topics that are embedded within, so wait for those posts if you want a detailed and simple (I know, it’s a paradox) explanation.

The Black Saturday brushfires of Australia was a devastating event that started on February 7th, 2009 and lasted until March 14th, 2009. Brushfires in Victoria, Australia are not uncommon, in fact there have been many brushfires ‘outbreaks’ in Victoria but non as devastating as this one. Victoria has the perfect climate for the dangerous brushfires

It is believed that the fires were started from different sources but mainly lighting and arson. Because of the climate of Victoria and the weather patterns, both prior and during the event, were the main cause for the outbreak. That year there was an extensive period where the rainfall amounts were dangerously below average. This was the long term cause for the brushfires. With respect to short term causes, the days leading up to the event as well as the days that followed displayed unusual and special meteorological conditions: high temperature, low humidity, and strong winds made for a deadly combination that fueled the fires.

In addition to the meteorological factors, there were numerous other factors, such as vegetation. Of course the vegetation factor can be linked to issues concerning the weather. As a result of little rainfall, the vegetation dried up and thus was able to serve as firewood.

During the actual event, the winds were one of the greatest problems to people. A method that is commonly used when fighting wildfires is back-burning. This is where you burn the vegetation that is in the path of the fire in order to contain it and prevent it from spreading onward. But the winds prevented this from being an effective method to end the destruction because it would change the path of the fire. In addition to changing the path, the winds would carry embers to other areas. Obviously this can cause more brushfires to occur and increase the destruction and the power of the system.

Now, one might ask the question of whether this is a result of global climate change or not. Some sources say that a link can be made while others argue against that claim. There is much more that needs to be uncovered within this event as well as global climate change. But it is known that water problems was a major cause for the drought in Australia and things are forecasted to become worse. With the water problems and drought-like conditions increasing in severity the brushfires in Australia will only become worse.

There is so much left to understand about this tragic event. Hopefully, as we discover more about the fires we will be able to prevent such horrors as this from happening. As for now, do your best to prevent wildfires from starting. It is really quite sad when nature is destroyed by such a preventable occurrence, and even sadder when communities, families, and lives are torn apart and burned by it.

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